1. Indicated for treatment of hypertension along or with other antihypertensive agents to lower blood pressure

1. To reduce the risk of stroke and systemic embolism in patients with non - valvular atrial fibrillation
2. For treatment of deep vein thrombosis and pulmonary embolism in patients who have been treated with parental anticoagulant for 5 - 10 days
3. To reduce the risk of recurrence of deep vein thrombosis and pulmonary embolism in patients who have been previously treated
4. For the prophylaxis of deep vein thrombolism and pulmonary embolism who have undergone hip replacement surgery

To reduce elevated LDL -C, Total - C, TG and Apo B, and to increase HDL - C in adult patients with primary hypercholesterolemia or mixed dyslipidemia, For treatment of adult patients with severe hypertriglyceridemia

For treatment of hypertension to lower blood pressure

Indicated for treatment of hypertension to lower blood pressure

1. Adult patients with primary hyperlipidemia and mixed dyslipideima as an adjuvant diet to reduce elevated total -C, LDL -C, ApoB, non HDL - C, and TG levels and to increase HDL - C levels
2. Pediatric patients 8 to 17 years of age with heterozygous familiar hypercholesterolemia to reduce elevated total - C, LDL -C and ApoB after failing adequate trail of diet therapy
3. Pediatric patients 7 to 17 years of age with homozygous familiar hypercholesterolemia to reduce LDL -C, total - C, non HDL - C and Apo B as an adjuvant to diet either alone or with other lipid lowering treatments,
4. Adult patients with hypertriglycerdemia as an adjuvant to diet, Adult patient with primary dysbetalipoprotinemia as an adjuvant to diet, Adult patient with homozygous familiar hypercholesterolemia to reduce LDL - C, total C and ApoB
5. Slowing the progress of atherosclerosis as part of a treatment strategy to lower total - C and LDL - C as an adjuvant to diet, Risk reduction of MI , Stroke and aterial revascularization procedures in patient without clinically evident CHD but with multiple risk factors

1. Schizoprenia
2. Acute treatment of manic and mixed episodes associated with Bipolar 1 disorder
3.Adjunctive treatment of major depressive disorder
4. Irritability associated with Autistic Disorder
5.Treatment of Tourette's disorder

For treatment of relpasing forms of multiple sclerosis to include clinically isolated syndrome, relapsing remitting disease, and active secondary progressive disease in adults

1. Major depressive disorder in adults
2. Generalized anxiety disorder in adults and pediatric patients 7 years of age and older
3. Diabetic peripheral neuropathic pain in adults
4. Fibromyalgia in adults and pediatric patients 13 years of age and older
5. Chronic muskuloskeletal pain in adults

Adjuvant Colon Cancer - Patients with Duke's C colon cancer, Metastatic Colorectal Cancer - First line as monotherapy when treatment with fluoropyrimidine therapy alone is preferred, Metastatic Breast Cancer - In combination with docetaxel after failure of prior anthracycline containing therapy, As monotherapy in patients resistant to both paclitaxel and an anthracycline containing regimen

1. Indicated for treatment of acute or chronic infections due to sensitive strains of certain gram negative bacilli
2. Particularly indicated when the infection is caused by sensitive strains of Pseudomonas aeruginosa

In adults and children in treatment for the treatment of following infections caused by susceptible Gram positive - Bacteria : Nosocomial pneumonia, Community acquired pneumonia, Complicated skin and skin structure infections, including diabetic foot infections, without concomitant osteomyelitis, Uncomplicated skin and skin structure infections, Vancomycin resistant Enterococcus faecium infections

1. For treating infections in adults 18 years of age and older caused by designated susceptible bacteria in conditions of community acquire pneumonia
2. Skin and Skin structure infections: Uncomplicated and complicated
3. Complicated intra abdominal infections
4. Plague
5. Acute Bacterial Sinusitis
6. Acute Bacterial Exacerbation of Chronic Bronchitis

For treatment of chronic hepatitis B virus infection in adults and children at least 2 years of age with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease

Immunocompetent Adult Patient:
1. Herpes Labialis -Treatment of recurrent episodes, Genital Herpes - Treatment of recurrent episodes, Supressive therapy of recurrent episodes, Herpes Zoster Human Immunodeficeincy Virus infected adult patients :
1. Treatment of recurrent episodes of orolabial or genital herpes

1. Indicated in combination with other antiviral agents for treatment of HIV - 1 infection in adult and pediatric patients 2 years of age and older weighing atleast 10kg
2. For treatment of Chronic hepatitis B in adult and pediatric patients 2 years and older weighing atleast 10kg

Adult patients:
1. Cold sores (Herpes labialis)
2. Genital herpes:
Treatment in immunocompetent patients (Initial or recurrent episode)
Suppression in immunocompetent or HIV infected patients
Reduction of transmission
Pediatric patients:
1. Cold sores (Herpes labialis)
2. Chickenpox

Adult patients:
1. Treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS)
2. Prevention of CMV disease in kidney, heart and kidney - pancreas transplant patients at high risk
Pediatric patients:
Prevention of CMV disease in kidney and heart transplant patients at high risk

Treatment of Gastroesophageal reflus disease (GERD), Risk reduction of NSAID -associated gastric ulcer, H. Pylori eradication to reduce the risk of duodenal ulcer recurrence, Pathological hypersecretory conditions, including Zollinger - Ellison syndrome

Short treatment of Gastroesophageal Reflux Disease with erosive esophagitis in adults and pediatric patients 1 month to 17 years of age, as an alternative to oral therapy when oral esomeprazole sodium is not possible or appropriate, Risk reduction of rebleeding of gastric or duodenal ulcers following the therapeutic endoscopy for acute bleeding or duodenal ulcers in adults

Indicated in adult for short term treatment ( 7 to 10 days) of gastroesophageal reflux disease associated with a history of Erosive esophagitis, Pathological hypersecretion conditions including Zollinger Ellison Syndrome

1. Symptomatic relief in treatment of osteoarthritis and rheumatoid arthritis
2. Symptomatic relief in treatment of ankylosing spondylitis
3. Treatment of pain and signs of inflammation associated with acute gouty arthritis Relief of chronic musculoskeletal pain
Relief of acute pain associated with dental surgery

1. Indicated for relief of symptoms associated with seasonal allergic rhinitis adults and children 6 years of age and older
2. For treatment of uncomplicated skin manifestations of chronic idiopathic utricaria in adults and children 6 years of age and older

1. For the relief of symptoms associated with perennial allergic rhinitis
2. For the treatment of uncomplicated skin manifestations of chronic idiopathic urticaria

1. Indicated for treatment of erectile dysfunction
2. The signs and symptoms of benign prostate hyperplasia
3. Erectile dysfunction and the signs and symptoms of benign prostate hyperplasia (ED/BPH)

Indicated in combination with other antiretroviral agents for treatment of HIV - 1 infection in adults and pediatric patients (14 days and older)