1. This product is dissolved in 2ml of water for injection, and can be injected intravenously, intramuscularly, arterial and intrathecally.
2. Used for acute leukemia: Injected intravenously and intramuscularly by 10-30mg each time, 1-2 times per week; For Children 20-30 mg / m2 daily, once a week, or depending on the actual situation of bone marrow.
3. Used for Ch-ep chorionepithelioma and Malignant hydatidiform mole: 10-20mg daily, it can also be dissolved in 500ml of 5% or 10% glucose injection intravenously, once daily, 5-10 times as a course of treatment. The total amount is 80 mg-100 mg.
4. Used for meningeal leukemia: Intrathecal injection of methotrexate is generally administered 6 mg/m2 each time, commonly used for adults 5-12 mg, the maximum dose is not more than 12 mg, once a day, 5 days as a course of treatment. For the prevention of meningeal leukemia, 10-15 mg daily, once a day, once every 6-8 weeks.
5. Used for solid tumors
（1） It is generally administered 20mg/m2 / time through Intravenous injection.
（2） Interventional therapy can also be used.
（3） High dose folic acid is administered for the treatment of some tumors, such as osteosarcoma etc..

Carboplatin for injection can be used alone or with other antineoplastic drug. Freshly dissolve this product by 5% Glucose injection to reach the concentration of 10mg/ml, then add to 250~500ml 5% Glucose injection, then perform intravenous drip. The recommended dose for adult is 0.2~0.4g/m², once every 3-4 weeks; 2-4 time for a course of treatment; alternatively, 50mg/m², once a day, for a consecutive 5 days, repeat the administration after a 4 week interval.

For adult, 1-2mg (or 1.4mg/m2), maximum less than 2mg; for adult over 65 years, maximum 1mg each time. For children, 75ug/kg or 2.0mg/m2, once a week by intravenous injection or intravenous infusion. The combined chemotherapy is consecutive 2 weeks for a cycle.

1. Dosage for Adult Chronic granulocytic leukemia, determine the dosage by considering the patient's current state of illness and the white blood cell count, normally the dose starts from 20-30mg/kg according to the weight, for oral administration once a day or separate the same dose into two portion for twice a day. If the white blood cell count falls below 10x109/L, reduce the dose to 20mg/kg daily, oral administration for maintenance or can be given intermittently. Head and neck cancer, ovarian cancer etc. The dose id 60-80mg/kg each time according to the weight, or 2000~3000mg/m², twice a week, take alone or can be used with radiotherapy; also dose can be 20-30mg/kg daily according to the weight, once a day orally.
2. Dose for children: not yet determined.

Take orally, three times a day, 2-4 tablets per day or follow the doctor's advice.

1. Mostly used dose for adult：
(1) Induced remission: intravenous injection or intravenous drip, each time 2mg/kg (or 1-3mg/kg) according to the weight, once a day for a consecutive 10-14 days. The dose can be increased to 4-6mg/kg each time according to the weight if there is none obvious adverse effect.
(2) Maintenance: apply the maintenance treatment dose after the symptom completely relieves, each time 1mg/kg according to the weight, 1-2 times a day by subcutaneous injection for a consecutive 7-10 days.
2. Medium dose of cytarabine: The medium dose refers to the dose of cytarabine is 0.5-1.0g/m2 according to the body surface area, and it usually needs to be intravenous dripped 1~3 hours, twice a day, with 2 ~ 6 days as a course of treatment; The dose of high dose of cytarabine is 1~3g/m2 according to the body surface area, and the intravenous drip and the course of treatment are the same as the medium dose. The medium-dose regimen is usually preferred Since the adverse effects of cytarabine increase with the dose and the adverse effects will limit its efficacy, Medium-or high-dose cytarabine is mainly administered for the treatment of refractory or relapsed acute leukemia, and can also be administered to prolong the remission period after the remission of acute leukemia. The course of treatment must be guided by an experienced physician and ensured by adequate and timely supportive therapy as the frequent occurrence of adverse effects .
3. The Low-dose cytarabine was injected subcutaneously once according to the body surface area of 10mg / m2, twice a day, with 14-21 days as a course of treatment which can be repeated in 2 to 3 weeks if the patient is not in remission and the patient's condition allows. This regimen is mainly used for the treatment of patients with primitive cellulocytosis or myelodysplastic syndrome, but also for the treatment of hypoproliferative acute leukemia and senile acute lymphoblastic leukemia.
4. Intrathecal injection of cytarabine is the second-line drug for the prevention and treatment of meningeal leukemia. The dose is 25-75mg once, combined with 5mg dexamethasone, dissolved with 2ml 0.9% sodium chloride injection, and injected intrathecally once or twice a week until the cerebrospinal fluid is normal. Once every 4-8 weeks if it is for preventive. Administration instructions: when administered this product, the liquid intake of patients shall be appropriately increased to keep the alkaline of urine, Allopurinol could be combined when necessary to prevent the increase of serum uric acid and the formation of uric acid nephropathy. Although rapid intravenous administration might cause severe nausea and vomiting, it had less inhibition on bone marrow, so that the patients could be more tolerant to large doses of cytarabine.

This product is not suitable for dissolving or diluting by acidic solution: glucose etc.
Primary hepatic carcinoma:
①intravenous injection, 4-6mg per day, dilute by adding 20ml 0.9% sodium chloride injection, then inject slowly, or follow the doctor's advice.
②hepatic artery injection, perfusion by taking 4mg, then add 10ml 0.9% sodium chloride injection, once a day, 15-30 days is a course of treatment.
Gastric cancer: intravenous injection, 4-6mg per day, dissolve by adding 20ml 0.9% sodium chloride injection, then inject slowly, or follow the doctor's advice.
Bladder cancer: hyperthermia for 100 minutes after the bladder perfusion, dose gradually increases to 20mg from 10mg, twice a week, 10-15 times is a course of treatment.
Rectal cancer: Intubation via the submesenteric artery, take 6-8mg Hydroxycamptothecin, add into 500ml 0.9% sodium chloride injection, arterial injection, once a day, 15-20 days is a course of treatment. Epithelial carcinoma of the head and neck, intravenous injection, 4-6 mg per day, dissolve by adding 20ml 0.9% sodium chloride injection, inject slowly, or follow the doctor's advice.
Leukemia: dose for adult is 6-8mg/m² daily according to the body surface area, add sodium chloride injection, intravenous drip, successive administration, 30 days is a course of treatment, or follow the doctor's advice.

Subcutaneous inkection. 2-4mg each time, once a day, apply injection every day or every other day, 3 months is a course of treatment or follow the doctor's advice. Freshly dissolve by adding 2ml sterilized water for injection, apply subcutaneous multi-point injection in armpits and groin area where there are plenty of lymphatic tissues.

For adults: NSCLC Monotherapy: The recommended dose for Gemcitabine is 1000mg/m2, carry out intravenous drip for 30 minutes. The drug should be given once a week and then rest for one week after 3 weeks' treatment. Repeat the above 4 weeks treatment cycle. The dose could be reduced in each treatment cycle or one treatment cycle according to the patient's tolerance to Gemcitabine. Combined treatment: For gemcitabine + cisplatin combination therapy, there are two therapeutic regimens: 3 weeks treatment and 4 weeks treatment. 3 weeks treatment: the recommended dose is 1250mg/m2, carry out intravenous drip for 30 minutes. The drug should be administered every 21 days on the 1st, 8th day of the treatment cycle. The dose could be reduced in each treatment cycle or one treatment cycle according to the patient's tolerance to Gemcitabine. 4 weeks treatment: the recommended dose is 1000mg/m2, carry out intravenous drip for 30 minutes. The drug should be administered every 28 days on the 1st, 8th and 15th day of the treatment cycle. The dose could be reduced in each treatment cycle or one treatment cycle according to the patient's tolerance to Gemcitabine. Pancreatic cancer The recommended dose for Gemcitabine is 1000mg/m2, carry out intravenous drip for 30 minutes. The drug shall be administered once a week for a consecutive 7 weeks, followed by a break of 1 week. The subsequent treatment cycle shall be changed to 4 weeks treatment: once a week, with a consecutive treatment for 3 weeks, and then followed by a break of 1 week. The dose could be reduced in each treatment cycle or one treatment cycle according to the patient's tolerance to Gemcitabine. Breast cancer Gemcitabine +paclitaxel combined chemotherapy is recommended. Paclitaxel(175mg/m2) shall be given every 21 days on the 1st day of the treatment cycle, carry out intravenous drip for about 3 hours. Then gemcitabine (1250mg / m2) should be administered intravenously for 30 minutes on the 1st and 8th days. The dose could be reduced in each treatment cycle or one treatment cycle according to the patient's tolerance to Gemcitabine. The absolute granulocyte count of patients shall be at least 1,500(x106/ L) before received Gemcitabine +paclitaxel combined chemotherapy.